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A two-trick pony: lysosomal protease cathepsin B possesses surprising ligase activity

Cathepsin B is an important protease within the lysosome, where it helps recycle proteins to maintain proteostasis. It is also known to degrade proteins elsewhere but has no other known functionality. However, by carefully monitoring peptide digestion with liquid chromatography and mass spectrometry...

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Detalhes bibliográficos
Publicado no:RSC Chem Biol
Main Authors: Lambeth, Tyler R., Dai, Zhefu, Zhang, Yong, Julian, Ryan R.
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291735/
https://ncbi.nlm.nih.gov/pubmed/34291207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cb00224k
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