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A two-trick pony: lysosomal protease cathepsin B possesses surprising ligase activity

Cathepsin B is an important protease within the lysosome, where it helps recycle proteins to maintain proteostasis. It is also known to degrade proteins elsewhere but has no other known functionality. However, by carefully monitoring peptide digestion with liquid chromatography and mass spectrometry...

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Vydáno v:RSC Chem Biol
Hlavní autoři: Lambeth, Tyler R., Dai, Zhefu, Zhang, Yong, Julian, Ryan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: RSC 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291735/
https://ncbi.nlm.nih.gov/pubmed/34291207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cb00224k
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