GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer

PURPOSE: Regulatory T cells (Tregs) heavily infiltrate triple-negative breast cancer (TNBC), and their accumulation is affected by the metabolic reprogramming in cancer cells. In the present study, we sought to identify cancer cell-intrinsic metabolic modulators correlating with Tregs infiltration i...

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Publicado en:J Immunother Cancer
Autores principales: Wei, Jin-Li, Wu, Si-Yu, Yang, Yun-Song, Xiao, Yi, Jin, Xi, Xu, Xiao-En, Hu, Xin, Li, Da-Qiang, Jiang, Yi-Zhou, Shao, Zhi-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291318/
https://ncbi.nlm.nih.gov/pubmed/34281987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002383
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