Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the mechanism that defines how immunosuppressive...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhai, Lijie, Bell, April, Ladomersky, Erik, Lauing, Kristen L., Bollu, Lakshmi, Sosman, Jeffrey A., Zhang, Bin, Wu, Jennifer D., Miller, Stephen D., Meeks, Joshua J., Lukas, Rimas V., Wyatt, Eugene, Doglio, Lynn, Schiltz, Gary E., McCusker, Robert H., Wainwright, Derek A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308527/
https://ncbi.nlm.nih.gov/pubmed/32612606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01185
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