Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the mechanism that defines how immunosuppressive...

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Detalhes bibliográficos
Main Authors: Lijie Zhai, April Bell, Erik Ladomersky, Kristen L. Lauing, Lakshmi Bollu, Jeffrey A. Sosman, Bin Zhang, Jennifer D. Wu, Stephen D. Miller, Joshua J. Meeks, Rimas V. Lukas, Eugene Wyatt, Lynn Doglio, Gary E. Schiltz, Robert H. McCusker, Derek A. Wainwright
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-06-01
Colecção:Frontiers in Immunology
Assuntos:
aging
immunotherapy
glioblastoma
tryptophan
immunosuppression
Treg
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.01185/full
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