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IMMU-20. ADVANCED AGING INCREASES IMMUNOSUPPRESSIVE IDO1 LEVELS THAT ARE UNINHIBITED BY IDO1 ENZYME INHIBITOR TREATMENT IN MODELS OF GLIOBLASTOMA

Immunotherapy has failed to improve the overall survival (OS) of adults with GBM in all phase III clinical trials to-date. Somewhat less appreciated is that, de novo GBM is a disease associated with a median age of diagnosis at 64 years old. Because of the strong association between advanced aging a...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Ladomersky, Erik, Zhai, Lijie, Lauing, Kristen, Qian, Jun, Otto-Meyer, Sebastian, Savoor, Rohan, Wainwright, Derek
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847513/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.513
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