IMMU-41. IDO1 INCREASES Treg RECRUITMENT INDEPENDENT OF TRYPTOPHAN METABOLISM IN A MODEL OF GLIOBLASTOMA

OBJECTIVE: Glioblastoma (GBM) patients with high intratumoral IDO1 mRNA levels have an associated decrease in survival (Zhai et al., 2017; CCR). IDO1 is an immunosuppressive mediator that metabolizes tryptophan (Trp), and through its associated enzyme activity, has long been recognized to increase i...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Zhai, Lijie, Qian, Jun, Ladomersky, Erik, Lauing, Kristen, Scholtens, Denise, Lukas, Rimas, Wainwright, Derek
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2018
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Abstracts
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216393/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.544
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