Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency

[Image: see text] Non-covalent inhibitors of the main protease (M(pro)) of SARS-CoV-2 having a pyridinone core were previously reported with IC(50) values as low as 0.018 μM for inhibition of enzymatic activity and EC(50) values as low as 0.8 μM for inhibition of viral replication in Vero E6 cells....

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zhang, Chun-Hui, Spasov, Krasimir A., Reilly, Raquel A., Hollander, Klarissa, Stone, Elizabeth A., Ippolito, Joseph A., Liosi, Maria-Elena, Deshmukh, Maya G., Tirado-Rives, Julian, Zhang, Shuo, Liang, Zhuobin, Miller, Scott J., Isaacs, Farren, Lindenbach, Brett D., Anderson, Karen S., Jorgensen, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291137/
https://ncbi.nlm.nih.gov/pubmed/34408808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00326
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