Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency

[Image: see text] Non-covalent inhibitors of the main protease (M(pro)) of SARS-CoV-2 having a pyridinone core were previously reported with IC(50) values as low as 0.018 μM for inhibition of enzymatic activity and EC(50) values as low as 0.8 μM for inhibition of viral replication in Vero E6 cells....

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :ACS Med Chem Lett
Главные авторы: Zhang, Chun-Hui, Spasov, Krasimir A., Reilly, Raquel A., Hollander, Klarissa, Stone, Elizabeth A., Ippolito, Joseph A., Liosi, Maria-Elena, Deshmukh, Maya G., Tirado-Rives, Julian, Zhang, Shuo, Liang, Zhuobin, Miller, Scott J., Isaacs, Farren, Lindenbach, Brett D., Anderson, Karen S., Jorgensen, William L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2021
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291137/
https://ncbi.nlm.nih.gov/pubmed/34408808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00326
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы