The third-generation EGFR inhibitor almonertinib (HS-10296) resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs

The overexpression of the human ATP-binding cassette (ABC) drug transporter ABCB1 (P-glycoprotein, P-gp) or ABCG2 (breast cancer resistance protein, BCRP) in cancer cells often contributes significantly to the development of multidrug resistance (MDR) in cancer patients. Previous reports have demons...

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Wu, Chung-Pu, Hung, Tai-Ho, Lusvarghi, Sabrina, Chu, Yi-Hsuan, Hsiao, Sung-Han, Huang, Yang-Hui, Chang, Yu-Tzu, Ambudkar, Suresh. V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291035/
https://ncbi.nlm.nih.gov/pubmed/33713643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2021.114516
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