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Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps

Acute pancreatitis (AP) is serious inflammatory disease of the pancreas. Accumulating evidence links diabetes with severity of AP, suggesting that endogenous insulin may be protective. We investigated this putative protective effect of insulin during cellular and in vivo models of AP in diabetic mic...

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Vydáno v:Nat Commun
Hlavní autoři: Bruce, Jason I. E., Sánchez-Alvarez, Rosa, Sans, Maria Dolors, Sugden, Sarah A., Qi, Nathan, James, Andrew D., Williams, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289871/
https://ncbi.nlm.nih.gov/pubmed/34282152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24506-w
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