The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP

Evidence suggests that the plasma membrane Ca(2+)-ATPase (PMCA), which is critical for maintaining a low intracellular Ca(2+) concentration ([Ca(2+)](i)), utilizes glycolytically derived ATP in pancreatic ductal adenocarcinoma (PDAC) and that inhibition of glycolysis in PDAC cell lines results in AT...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: James, Andrew D., Patel, Waseema, Butt, Zohra, Adiamah, Magretta, Dakhel, Raga, Latif, Ayse, Uggenti, Carolina, Swanton, Eileithyia, Imamura, Hiromi, Siriwardena, Ajith K., Bruce, Jason I. E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598988/
https://ncbi.nlm.nih.gov/pubmed/26294767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668707
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