Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation

Transforming growth factor-β (TGFβ) is a key mediator of fibroblast activation in fibrotic diseases, including systemic sclerosis. Here we show that Engrailed 1 (EN1) is reexpressed in multiple fibroblast subpopulations in the skin of SSc patients. We characterize EN1 as a molecular amplifier of TGF...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Györfi, Andrea-Hermina, Matei, Alexandru-Emil, Fuchs, Maximilian, Liang, Chunguang, Rigau, Aleix Rius, Hong, Xuezhi, Zhu, Honglin, Luber, Markus, Bergmann, Christina, Dees, Clara, Ludolph, Ingo, Horch, Raymund E., Distler, Oliver, Wang, Jiucun, Bengsch, Bertram, Schett, Georg, Kunz, Meik, Distler, Jörg H.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288503/
https://ncbi.nlm.nih.gov/pubmed/34259830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201916
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