Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

Autoimmunity, microangiopathy and tissue fibrosis are hallmarks of systemic sclerosis (SSc). Vascular alterations and reduced capillary density decrease blood flow and impair tissue oxygenation in SSc. Oxygen supply is further reduced by accumulation of extracellular matrix (ECM), which increases di...

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Bibliographic Details
Main Authors: Beyer, Christian, Schett, Georg, Gay, Steffen, Distler, Oliver, Distler, Jörg HW
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688169/
https://ncbi.nlm.nih.gov/pubmed/19473554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2598
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