Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation

Transforming growth factor-β (TGFβ) is a key mediator of fibroblast activation in fibrotic diseases, including systemic sclerosis. Here we show that Engrailed 1 (EN1) is reexpressed in multiple fibroblast subpopulations in the skin of SSc patients. We characterize EN1 as a molecular amplifier of TGF...

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Udgivet i:J Exp Med
Main Authors: Györfi, Andrea-Hermina, Matei, Alexandru-Emil, Fuchs, Maximilian, Liang, Chunguang, Rigau, Aleix Rius, Hong, Xuezhi, Zhu, Honglin, Luber, Markus, Bergmann, Christina, Dees, Clara, Ludolph, Ingo, Horch, Raymund E., Distler, Oliver, Wang, Jiucun, Bengsch, Bertram, Schett, Georg, Kunz, Meik, Distler, Jörg H.W.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288503/
https://ncbi.nlm.nih.gov/pubmed/34259830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201916
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