Immunomodulatory effects of pevonedistat, a NEDD8-activating enzyme inhibitor, in chronic lymphocytic leukemia-derived T cells

Novel targeted agents used in therapy of lymphoid malignancies, such as inhibitors of B-cell receptor-associated kinases, are recognized to have complex immune-mediated effects. NEDD8-activating enzyme (NAE) has been identified as a tractable target in chronic lymphocytic leukemia (CLL) and non-Hodg...

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Pubblicato in:Leukemia
Autori principali: Best, Scott, Lam, Vi, Liu, Tingting, Bruss, Nur, Kittai, Adam, Danilova, Olga V., Murray, Susan, Berger, Allison, Pennock, Nathan D., Lind, Evan F., Danilov, Alexey V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288064/
https://ncbi.nlm.nih.gov/pubmed/32203139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0794-0
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