Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library

We performed in vitro selection experiments to identify DNA aptamers for the S1 subunit of the SARS-CoV-2 spike protein (S1 protein). Using a pool of pre-structured random DNA sequences, we obtained over 100 candidate aptamers after 13 cycles of enrichment under progressively more stringent selectio...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Li, Jiuxing, Zhang, Zijie, Gu, Jimmy, Stacey, Hannah D, Ang, Jann C, Capretta, Alfredo, Filipe, Carlos D M, Mossman, Karen L, Balion, Cynthia, Salena, Bruno J, Yamamura, Deborah, Soleymani, Leyla, Miller, Matthew S, Brennan, John D, Li, Yingfu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Chemical Biology and Nucleic Acid Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287928/
https://ncbi.nlm.nih.gov/pubmed/34232998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab574
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