p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino

Many long noncoding RNA (lncRNA) genes exist near cancer-associated loci, yet evidence connecting lncRNA functions to recurrent genetic alterations in cancer are lacking. Here, we report that DINO, the lncRNA transcribed from the cancer-associated DINO/CDKN1A locus, suppresses tumor formation indepe...

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Udgivet i:Cell Rep
Main Authors: Marney, Christina B., Anderson, Erik S., Adnan, Mutayyaba, Peng, Kai-Lin, Hu, Ya, Weinhold, Nils, Schmitt, Adam M.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287872/
https://ncbi.nlm.nih.gov/pubmed/34192538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109329
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