Long noncoding RNA PURPL suppresses basal p53 levels and promotes tumorigenicity in colorectal cancer

Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis and tumor suppression. Here, we report the suppression of basal p53 levels by a nuclear, p53-regulated long noncoding RNA that we termed P...

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Publicado no:Cell Rep
Main Authors: Li, Xiao Ling, Subramanian, Murugan, Jones, Matthew F., Chaudhary, Ritu, Singh, Deepak K., Zong, Xinying, Gryder, Berkley, Sindri, Sivasish, Mo, Min, Schetter, Aaron, Wen, Xinyu, Parvathaneni, Swetha, Kazandjian, Dickran, Jenkins, Lisa M., Tang, Wei, Elloumi, Fathi, Martindale, Jennifer L., Huarte, Maite, Zhu, Yuelin, Robles, Ana I., Frier, Susan M., Rigo, Frank, Cam, Maggie, Ambs, Stefan, Sharma, Sudha, Harris, Curtis C., Dasso, Mary, Prasanth, Kannanganattu V., Lal, Ashish
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777516/
https://ncbi.nlm.nih.gov/pubmed/28877474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.041
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