Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the function of the vast majority remains unclear. Here, we show that a p53-regulated lncRNA which we named PINCR (p53-induced noncoding RNA), is induced ~100-fold after DNA damage and exerts a prosurvival function in human colorec...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chaudhary, Ritu, Gryder, Berkley, Woods, Wendy S, Subramanian, Murugan, Jones, Matthew F, Li, Xiao Ling, Jenkins, Lisa M, Shabalina, Svetlana A, Mo, Min, Dasso, Mary, Yang, Yuan, Wakefield, Lalage M, Zhu, Yuelin, Frier, Susan M, Moriarity, Branden S, Prasanth, Kannanganattu V, Perez-Pinera, Pablo, Lal, Ashish
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470874/
https://ncbi.nlm.nih.gov/pubmed/28580901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23244
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