Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes

Axonal generation of Alzheimer’s disease (AD)-associated amyloid-β (Aβ) plays a key role in AD neuropathology, but the cellular mechanisms involved in its release have remained elusive. We previously reported that palmitoylated APP (palAPP) partitions to lipid rafts where it serves as a preferred su...

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Udgivet i:Cell Rep
Main Authors: Bhattacharyya, Raja, Black, Sophia E., Lotlikar, Madhura S., Fenn, Rebecca H., Jorfi, Mehdi, Kovacs, Dora M., Tanzi, Rudolph E.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287518/
https://ncbi.nlm.nih.gov/pubmed/34010653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109134
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