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Reversible Covalent PROTACs: Novel and Efficient Targeted Degradation Strategy

The proteolysis targeting chimeras (PROTACs), which are composed of a target protein binding moiety, a linker, and an E3 ubiquitin ligase binder, have been a promising strategy for drug design and discovery. Given the advantages of potency, selectivity, and drug resistance over inhibitors, several P...

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Detalhes bibliográficos
Publicado no:Front Chem
Principais autores: Yuan, Minghua, Chu, Yanan, Duan, Yongtao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287302/
https://ncbi.nlm.nih.gov/pubmed/34291036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.691093
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