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Degradation from the outside-in: targeting extracellular and membrane proteins for degradation through the endo-lysosomal pathway

Targeted protein degradation (TPD) is a promising strategy to remove deleterious proteins for therapeutic benefit and to probe biological pathways. The past two decades have witnessed a surge in the development of technologies that rely on intracellular machinery to degrade challenging cytosolic tar...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Ahn, Green, Banik, Steven M., Bertozzi, Carolyn R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286304/
https://ncbi.nlm.nih.gov/pubmed/33770486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2021.02.024
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