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Degradation from the outside-in: targeting extracellular and membrane proteins for degradation through the endo-lysosomal pathway
Targeted protein degradation (TPD) is a promising strategy to remove deleterious proteins for therapeutic benefit and to probe biological pathways. The past two decades have witnessed a surge in the development of technologies that rely on intracellular machinery to degrade challenging cytosolic tar...
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| Pubblicato in: | Cell Chem Biol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8286304/ https://ncbi.nlm.nih.gov/pubmed/33770486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2021.02.024 |
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