Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa

Pseudomonas aeruginosa is an opportunistic pathogen that forms antibiotic-resistant biofilms, which facilitate chronic infections in immunocompromised hosts. We have previously shown that P. aeruginosa secretes outer-membrane vesicles that deliver a small RNA to human airway epithelial cells (AECs),...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Koeppen, Katja, Nymon, Amanda, Barnaby, Roxanna, Bashor, Laura, Li, Zhongyou, Hampton, Thomas H., Liefeld, Amanda E., Kolling, Fred W., LaCroix, Ian S., Gerber, Scott A., Hogan, Deborah A., Kasetty, Swetha, Nadell, Carey D., Stanton, Bruce A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285967/
https://ncbi.nlm.nih.gov/pubmed/34260396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2105370118
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