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Calcium channel blockers do not protect against saturated fatty acid-induced ER stress and apoptosis in human pancreatic β-cells

It was evidenced that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to endoplasmic reticulum (ER) calcium release, ER stress, and apoptosis. In the present study, we have tested the effect of three calcium influx inhibitors, i.e., diazoxid...

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Publicat a:Nutr Metab (Lond)
Autors principals: Šrámek, Jan, Němcová, Vlasta, Kovář, Jan
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285784/
https://ncbi.nlm.nih.gov/pubmed/34274001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-021-00597-6
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