Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences

In the endocrine pancreas, growth hormone (GH) is known to promote pancreatic islet growth and insulin secretion. In this study, we show that GH receptor (GHR) loss in the germline and in adulthood impacts islet mass in general but more profoundly in male mice. GHR knockout (GHRKO) mice have enhance...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Duran-Ortiz, Silvana, Corbin, Kathryn L., Jahan, Ishrat, Whitticar, Nicholas B., Morris, Sarah E., Bartholomew, Ania N., Slepchenko, Kira G., West, Hannah L., Max Harry, Ibiagbani Mercy, List, Edward O., Kopchick, John J., Nunemaker, Craig S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285598/
https://ncbi.nlm.nih.gov/pubmed/33938235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00075.2020
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