Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences

In the endocrine pancreas, growth hormone (GH) is known to promote pancreatic islet growth and insulin secretion. In this study, we show that GH receptor (GHR) loss in the germline and in adulthood impacts islet mass in general but more profoundly in male mice. GHR knockout (GHRKO) mice have enhance...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Am J Physiol Endocrinol Metab
Autori principali: Duran-Ortiz, Silvana, Corbin, Kathryn L., Jahan, Ishrat, Whitticar, Nicholas B., Morris, Sarah E., Bartholomew, Ania N., Slepchenko, Kira G., West, Hannah L., Max Harry, Ibiagbani Mercy, List, Edward O., Kopchick, John J., Nunemaker, Craig S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2021
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285598/
https://ncbi.nlm.nih.gov/pubmed/33938235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00075.2020
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi