Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

While various GPCRs, including US28, display constitutive, ligand-independent activity, it remains to be established whether ligand-dependent and -independent active conformations differ and can be selectively modulated. Previously, the agonist-bound conformation of US28 was stabilized and its struc...

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Vydáno v:Nat Commun
Hlavní autoři: De Groof, Timo W. M., Bergkamp, Nick D., Heukers, Raimond, Giap, Truc, Bebelman, Maarten P., Goeij-de Haas, Richard, Piersma, Sander R., Jimenez, Connie R., Garcia, K. Christopher, Ploegh, Hidde L., Siderius, Marco, Smit, Martine J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285524/
https://ncbi.nlm.nih.gov/pubmed/34272386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24574-y
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