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Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies

Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent HCMV in immunosuppressed solid organ and stem cell transplant patients often results...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: De Groof, Timo W. M., Elder, Elizabeth G., Lim, Eleanor Y., Heukers, Raimond, Bergkamp, Nick D., Groves, Ian J., Wills, Mark, Sinclair, John H., Smit, Martine J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295288/
https://ncbi.nlm.nih.gov/pubmed/34290252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24608-5
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