Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure

Genetic deletion of Sam68, a pleiotropic adaptor protein prevents high-fat-diet–induced weight gain and insulin resistance. To clarify the role of Sam68 in energy metabolism in the adult stage, we generated an inducible Sam68 knockout mice. Knockout of Sam68 was induced at the age of 7-10 weeks, and...

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Veröffentlicht in:FASEB J
Hauptverfasser: Qiao, Aijun, Ma, Wenxia, Deng, Jianxin, Zhou, Junlan, Han, Chaoshan, Zhang, Eric, Boriboun, Chan, Xu, Shiyue, Zhang, Chunxiang, Jie, Chunfa, Kim, Jeong-a, Habegger, Kirk, Qiu, Hongyu, Zhao, Ting C, Zhang, Jianyi, Qin, Gangjian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285032/
https://ncbi.nlm.nih.gov/pubmed/34252225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202100021R
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