Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage

Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in aged mice, neutrophils adhered to vascular endothelium in inflamed tissues but exhibited a high frequency of reverse transe...

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Detaylı Bibliyografya
Yayımlandı:Immunity
Asıl Yazarlar: Barkaway, Anna, Rolas, Loïc, Joulia, Régis, Bodkin, Jennifer, Lenn, Tchern, Owen-Woods, Charlotte, Reglero-Real, Natalia, Stein, Monja, Vázquez-Martínez, Laura, Girbl, Tamara, Poston, Robin N., Golding, Matthew, Saleeb, Rebecca S., Thiriot, Aude, von Andrian, Ulrich H., Duchene, Johan, Voisin, Mathieu-Benoit, Bishop, Cleo L., Voehringer, David, Roers, Axel, Rot, Antal, Lämmermann, Tim, Nourshargh, Sussan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284598/
https://ncbi.nlm.nih.gov/pubmed/34033752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.04.025
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