Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage

Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in aged mice, neutrophils adhered to vascular endothelium in inflamed tissues but exhibited a high frequency of reverse transe...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Barkaway, Anna, Rolas, Loïc, Joulia, Régis, Bodkin, Jennifer, Lenn, Tchern, Owen-Woods, Charlotte, Reglero-Real, Natalia, Stein, Monja, Vázquez-Martínez, Laura, Girbl, Tamara, Poston, Robin N., Golding, Matthew, Saleeb, Rebecca S., Thiriot, Aude, von Andrian, Ulrich H., Duchene, Johan, Voisin, Mathieu-Benoit, Bishop, Cleo L., Voehringer, David, Roers, Axel, Rot, Antal, Lämmermann, Tim, Nourshargh, Sussan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284598/
https://ncbi.nlm.nih.gov/pubmed/34033752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.04.025
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