Efficacy of Antistaphylococcal Lysin LSVT-1701 in Combination with Daptomycin in Experimental Left-Sided Infective Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

We utilized the rabbit model of aortic valve infective endocarditis to examine the combined efficacy of the lysin LSVT-1701 plus daptomycin. The combination of LSVT-1701 plus daptomycin was highly effective at reducing methicillin-resistant Staphylococcus aureus (MRSA) counts in target tissue. When...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Huang, David B., Gaukel, Eric, Kerzee, Nancy, Borroto-Esoda, Katyna, Lowry, Simon, Xiong, Yan Q., Abdelhady, Wessam, Bayer, Arnold S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284455/
https://ncbi.nlm.nih.gov/pubmed/34097491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00508-21
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