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Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics
The β-lactamase of Mycobacterium tuberculosis, BlaC, is susceptible to inhibition by clavulanic acid. The ability of this enzyme to escape inhibition through mutation was probed using error-prone PCR combined with functional screening in Escherichia coli. The variant that was found to confer the mos...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Antimicrob Agents Chemother |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8284444/ https://ncbi.nlm.nih.gov/pubmed/34031049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02628-20 |
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