Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics

The β-lactamase of Mycobacterium tuberculosis, BlaC, is susceptible to inhibition by clavulanic acid. The ability of this enzyme to escape inhibition through mutation was probed using error-prone PCR combined with functional screening in Escherichia coli. The variant that was found to confer the mos...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Elings, Wouter, Chikunova, Aleksandra, van Zanten, Danny B., Drenth, Ralphe, Ahmad, Misbha Ud Din, Blok, Anneloes J., Timmer, Monika, Perrakis, Anastassis, Ubbink, Marcellus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284444/
https://ncbi.nlm.nih.gov/pubmed/34031049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02628-20
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