Phosphate Promotes the Recovery of Mycobacterium tuberculosis β-Lactamase from Clavulanic Acid Inhibition

[Image: see text] The rise of multi- and even totally antibiotic resistant forms of Mycobacterium tuberculosis underlines the need for new antibiotics. The pathogen is resistant to β-lactam compounds due to its native serine β-lactamase, BlaC. This resistance can be circumvented by administration of...

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Udgivet i:Biochemistry
Main Authors: Elings, Wouter, Tassoni, Raffaella, van der Schoot, Steven A., Luu, Wendy, Kynast, Josef P., Dai, Lin, Blok, Anneloes J., Timmer, Monika, Florea, Bogdan I., Pannu, Navraj S., Ubbink, Marcellus
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707625/
https://ncbi.nlm.nih.gov/pubmed/29087696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00556
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