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Structure and mechanism of Mycobacterium smegmatis polynucleotide phosphorylase

Polynucleotide phosphorylase (PNPase) catalyzes stepwise phosphorolysis of the 3′-terminal phosphodiesters of RNA chains to yield nucleoside diphosphate products. In the reverse reaction, PNPase acts as a polymerase, using NDPs as substrates to add NMPs to the 3′-OH terminus of RNA chains while expe...

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Enregistré dans:
Détails bibliographiques
Publié dans:RNA
Auteurs principaux: Unciuleac, Mihaela-Carmen, Ghosh, Shreya, de la Cruz, M. Jason, Goldgur, Yehuda, Shuman, Stewart
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284320/
https://ncbi.nlm.nih.gov/pubmed/34088850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.078822.121
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