Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank

To investigate cross-ancestry genetics of complex traits, we conducted a phenome-wide analysis of loci with heterogeneous effects across African, Admixed-American, Central/South Asian, East Asian, European and Middle Eastern participants of the UK Biobank (N = 441 331). Testing 843 phenotypes, we id...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: De Lillo, Antonella, D'Antona, Salvatore, Pathak, Gita A, Wendt, Frank R, De Angelis, Flavio, Fuciarelli, Maria, Polimanti, Renato
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Association Studies Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283210/
https://ncbi.nlm.nih.gov/pubmed/33890984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab114
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