Epigenomic Profiles of African American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms

BACKGROUND -: The Val122Ile mutation in Transthyretin (TTR) gene causes a rare, difficult to diagnose hereditary form of cardiac amyloidosis. This mutation is most common in the United States and mainly present in people of African descent. The carriers have an increased risk of congestive heart fai...

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Publicado en:Circ Genom Precis Med
Main Authors: Pathak, Gita A., Wendt, Frank R., De Lillo, Antonella, Nunez, Yaira Z., Goswami, Aranyak, De Angelis, Flavio, Fuciarelli, Maria, Kranzler, Henry R., Gelernter, Joel, Polimanti, Renato
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887108/
https://ncbi.nlm.nih.gov/pubmed/33428857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.120.003011
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