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Molecular dynamics simulation study of AG10 and tafamidis binding to the Val122Ile transthyretin variant
Molecular dynamics (MD) simulations were used to investigate the binding of four ligands to the Val122Ile mutant of the protein transthyretin. Dissociation, misfolding, and subsequent aggregation of mutated transthyretin proteins are associated with the disease Familial Amyloidal Cardiomyopathy. The...
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| Vydáno v: | Biochem Biophys Rep |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Elsevier
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7005373/ https://ncbi.nlm.nih.gov/pubmed/32055713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2019.100721 |
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