Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity

BACKGROUND: Obesity can cause hypertension and exacerbates sleep-disordered breathing (SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate, suppresses appetite, modulates control of breathing, and increases blood pressure. Obese individuals with high circulating levels of l...

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Publicat a:Front Physiol
Autors principals: Kim, Lenise J., Shin, Mi-Kyung, Pho, Huy, Otvos, Laszlo, Tufik, Sergio, Andersen, Monica L., Pham, Luu V., Polotsky, Vsevolod Y.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283021/
https://ncbi.nlm.nih.gov/pubmed/34276408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.688375
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