Intratumor morphologic and transcriptomic heterogeneity in (V600E)BRAF-mutated metastatic colorectal adenocarcinomas

BACKGROUND: Intratumor heterogeneity (ITH) is described as the presence of various clones within one tumor, each with their own unique features in terms of morphology, inflammation, genetics or transcriptomics. Heterogeneity provides the fuel for drug resistance; therefore, an accurate assessment of...

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Vydáno v:ESMO Open
Hlavní autoři: Angerilli, V., Fontana, E., Lonardi, S., Sbaraglia, M., Borelli, B., Munari, G., Salmaso, R., Guzzardo, V., Spolverato, G., Pucciarelli, S., Pilati, P., Hahne, J.C., Bergamo, F., Zagonel, V., Dei Tos, A.P., Sadanandam, A., Loupakis, F., Valeri, N., Fassan, M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282957/
https://ncbi.nlm.nih.gov/pubmed/34271310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.esmoop.2021.100211
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