Intratumor morphologic and transcriptomic heterogeneity in (V600E)BRAF-mutated metastatic colorectal adenocarcinomas

BACKGROUND: Intratumor heterogeneity (ITH) is described as the presence of various clones within one tumor, each with their own unique features in terms of morphology, inflammation, genetics or transcriptomics. Heterogeneity provides the fuel for drug resistance; therefore, an accurate assessment of...

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Veröffentlicht in:ESMO Open
Hauptverfasser: Angerilli, V., Fontana, E., Lonardi, S., Sbaraglia, M., Borelli, B., Munari, G., Salmaso, R., Guzzardo, V., Spolverato, G., Pucciarelli, S., Pilati, P., Hahne, J.C., Bergamo, F., Zagonel, V., Dei Tos, A.P., Sadanandam, A., Loupakis, F., Valeri, N., Fassan, M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282957/
https://ncbi.nlm.nih.gov/pubmed/34271310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.esmoop.2021.100211
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