Intratumor morphologic and transcriptomic heterogeneity in (V600E)BRAF-mutated metastatic colorectal adenocarcinomas

BACKGROUND: Intratumor heterogeneity (ITH) is described as the presence of various clones within one tumor, each with their own unique features in terms of morphology, inflammation, genetics or transcriptomics. Heterogeneity provides the fuel for drug resistance; therefore, an accurate assessment of...

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Dades bibliogràfiques
Publicat a:ESMO Open
Autors principals: Angerilli, V., Fontana, E., Lonardi, S., Sbaraglia, M., Borelli, B., Munari, G., Salmaso, R., Guzzardo, V., Spolverato, G., Pucciarelli, S., Pilati, P., Hahne, J.C., Bergamo, F., Zagonel, V., Dei Tos, A.P., Sadanandam, A., Loupakis, F., Valeri, N., Fassan, M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282957/
https://ncbi.nlm.nih.gov/pubmed/34271310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.esmoop.2021.100211
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