Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway

Alcohol-related liver disease (ALD), a condition caused by alcohol overconsumption, occurs in three stages of liver injury including steatosis, hepatitis, and cirrhosis. DEP domain-containing protein 5 (DEPDC5), a component of GAP activities towards Rags 1 (GATOR1) complex, is a repressor of amino a...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xu, Lin, Zhang, Xinge, Xin, Yue, Ma, Jie, Yang, Chenyan, Zhang, Xi, Hou, Guoqing, Dong, Xiaocheng Charlie, Sun, Zhaoli, Xiong, Xiwen, Cao, Xuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282792/
https://ncbi.nlm.nih.gov/pubmed/34267188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03980-6
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