Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2

Across species, hematopoietic stem and progenitor cells (HSPCs) arise during embryogenesis from a specialized arterial population, termed hemogenic endothelium. Here, we describe a mechanistic role for the epigenetic regulator, Enhancer of zeste homolog-1 (Ezh1), in vertebrate HSPC production via re...

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Publicat a:Stem Cell Reports
Autors principals: Soto, Rebecca A., Najia, Mohamad Ali T., Hachimi, Mariam, Frame, Jenna M., Yette, Gabriel A., Lummertz da Rocha, Edroaldo, Stankunas, Kryn, Daley, George Q., North, Trista E.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282472/
https://ncbi.nlm.nih.gov/pubmed/34143974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.05.014
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