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Definitive hematopoiesis in the yolk sac emerges from Wnt-responsive hemogenic endothelium independently of circulation and arterial identity

Adult-repopulating hematopoietic stem cells (HSCs) emerge in low numbers in the midgestation mouse embryo from a subset of arterial endothelium, through an endothelial-to-hematopoietic transition. HSC-producing arterial hemogenic endothelium relies on the establishment of embryonic blood flow and ar...

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Bibliografske podrobnosti
izdano v:Stem Cells
Main Authors: Frame, Jenna M., Fegan, Katherine H., Conway, Simon J., McGrath, Kathleen E., Palis, James
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755868/
https://ncbi.nlm.nih.gov/pubmed/26418893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2213
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