Mechanisms of angiogenic incompetence in Hutchinson–Gilford progeria via downregulation of endothelial NOS

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder with features of accelerated aging. The majority of HGPS cases are caused by a de novo point mutation in the LMNA gene (c.1824C>T; p.G608G) resulting in progerin, a toxic lamin A protein variant. Children with HGPS typically d...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Gete, Yantenew G., Koblan, Luke W., Mao, Xiaojing, Trappio, Mason, Mahadik, Bhushan, Fisher, John P., Liu, David R., Cao, Kan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282277/
https://ncbi.nlm.nih.gov/pubmed/34086398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13388
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