In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial

BACKGROUND: Loss of mitochondrial function contributes to fatigue, exercise intolerance and muscle weakness, and is a key factor in the disability that develops with age and a wide variety of chronic disorders. Here, we describe the impact of a first-in-class cardiolipin-binding compound that is tar...

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Publicado en:PLoS One
Main Authors: Roshanravan, Baback, Liu, Sophia Z., Ali, Amir S., Shankland, Eric G., Goss, Chessa, Amory, John K., Robertson, H. Thomas, Marcinek, David J., Conley, Kevin E.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282018/
https://ncbi.nlm.nih.gov/pubmed/34264994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0253849
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