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Impaired Adaptability of in Vivo Mitochondrial Energetics to Acute Oxidative Insult in Aged Skeletal Muscle

Periods of elevated reactive oxygen species (ROS) production are a normal part of mitochondrial physiology. However, little is known about age-related changes in the mitochondrial response to elevated ROS in vivo. Significantly, ROS-induced uncoupling of oxidative phosphorylation has received attent...

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Detalhes bibliográficos
Main Authors: Siegel, Michael P., Wilbur, Tim, Mathis, Mark, Shankland, Eric, Trieu, Atlas, Harper, Mary-Ellen, Marcinek, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3456966/
https://ncbi.nlm.nih.gov/pubmed/22935551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.08.002
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